MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Summary: Hematopoiesis is particularly sensitive to DNA damage.Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy.It is not known why hematopoietic cells are highly vulnerable to DNA damage.Addressing this question is complicated by the paucity pax 3 onyx of mouse models of hematopoietic malignancies due to

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